We are delighted to announce that Actuate Therapeutics is the latest company to join the Kairos portfolio.
Founded in 2015 Actuate Therapeutics is a clinical-stage pharmaceutical company focused on the development and commercialization of novel therapeutic agents for patients with cancer or inflammatory diseases.
“We are quickly advancing the 1801 clinical trial of 9-ING-41 in adult cancer patients in the US. The financing allows us to expand the 1801 clinical trial out to our world-leading oncology research institution network in the US and Europe; to initiate Investigator Initiated Trials being developed with our physician/scientist collaborators; and to advance our pediatric neuroblastoma program.”
– Daniel Schmitt, President & CEO of Actuate
Actuate will use the proceeds of the financing to expand the company’s ongoing Phase 1 / 2 clinical trial and fund development programs. “We are quickly advancing the 1801 clinical trial of 9-ING-41 in adult cancer patients in the US. The financing allows us to expand the 1801 clinical trial out to our world-leading oncology research institution network in the US and Europe; to initiate Investigator Initiated Trials being developed with our physician/scientist collaborators; and to advance our pediatric neuroblastoma program” said Daniel Schmitt, President & CEO of Actuate.
Earlier this year at Brown University/Rhode Island Hospital, the first patient was treated in the Actuate 1801: Phase 1/2 Study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3β) Inhibitor, as a Single Agent and Combined with Chemotherapy, in Patients with Refractory Hematologic Malignancies or Solid Tumors (https://clinicaltrials.gov/ct2/show/study/NCT03678883).
The 1801 study is now actively recruiting patients at the following institutions:
o Brown University Rhode Island Hospital – Providence, RI
o UCSF Helen Diller Family Comprehensive Cancer Center – San Francisco, CA
o Miami Cancer Institute – Miami, FL
o Mayo Clinic – Rochester, MN
o Sanford Research – Sioux Falls, SD
“We continue to have a dynamic and productive collaboration on the 1801 study with global leaders in the oncology field,” said Dr. Frank Giles, Actuate’s Chief Medical Officer. “Their appreciation of, and involvement in, the very meticulous design of the study, based on the safest conduct that will facilitate the generation of clear data on 9-ING-41, is reflected in the robust study patient accrual we have experienced to date. Our collaborations with expert colleagues on the development of Investigator Initiated Trials will rapidly expand our knowledge beyond that derived from the 1801 study, and these studies are a high priority for us. We are also focused on using the initial 1801 study data to inform the design of 9-ING-41 regimens for children and adolescents with refractory tumors, with an initial focus on neuroblastoma, where 9-ING-41’s pre-clinical activity is noteworthy.”
As part of the investment, Alex Adrianopoulos joins the Actuate Therapeutics board. We are thrilled about our investment in Actuate Therapeutics and welcome them to the extended Kairos Ventures family!
